The expression of bFGF in oral ulcer model of rabbits / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6): 43-46, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-697451
ABSTRACT
Objective:
To detect the expression of basic fibroblast growth factor(bFGF) in oral mucosa with ulcer in rabbits.Methods:
72 New Zealand rabbits(with the weight of 3 000-3 500 g) were randomly divided into control group,model group,and treatment group(n = 24). 1,3,5 and 7 d after treatment buccal mucous membrane tissues of the rabbits were respectively taken from the 3 groups. The models of oral ulcer were examined by HE staining. The expression of bFGF mRNA was detected by RTPCR. The expression of bFGF protein was detected by immunohistochemistry.Results:
The oral ulcer model of the rabbits was successfully established. Both RT-PCR and immunohistochemistry analyses showed that 1-7 d after treatment the expression levels of bFGF mRNA and protein were higher in treatment group than in model group(P < 0. 05) and control group(P < 0. 05),3-7 d after treatment were higher than in model group(P> 0. 05).Conclusion:
bFGF may be a new therapeutic target for oral ulcer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Practical Stomatology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS