Expression and clinical analysis of snail in 41 patients with non small cell lung cancer / 实用医学杂志

ABSTRACT

Objective To study the expressions of snail mRNA and protein in human non-small cell lung cancer (NSCLC) and their correlations to patient clinical features.Methods Real-time fluores-cence quantitative PCR (qRT-PCR) and immunohistochemical were used to analyze the expressions of snail in a total of 41 pairs of NSCLC tissues,12 specimens of normal lung tissues.Results The expressions of snail mRNA in NSCLC tissues were significantly higher than the corresponding adjacent tissues (P ＜ 0.01).The expression rate of snail protein of NSCLC tissues (25/41) were significantly higher than that in adjacent tissues (2/41,P ＜ 0.01).There was no snail expression in non-cancerous lung tissues.The level of mRNA and protein in snail was associated with lymph node metastasis and clinical stage of non-small cell lung cancer (P ＜ 0.05).Conclusion The higher expression of snail may promote the metastasis of lung cancer.The expressions of snail are related to the development of human non-small cell lung cancer.