Association of EPHX2 rs 751141 polymorphisms with coronary heart disease / 实用医学杂志

ABSTRACT

Objective To study the correlation between EPHX2 gene rs751141 polymorphisms and coronary heart disease (CHD) in Chinese population.Methods Totally 108 patients having more than one major coronary vessel with at least 50％ stenosis defined by Coronary angiography were selected as CHD group and control group consisted of 112 healthy subjects.Rs751141 polymorphisms were detected by PCR and gene sequence.Results Three kinds of genotypes at the rs751141 were detected,and no deviation was observed from HardyWeinberg equilibrium.There was statistical difference between the two groups regarding the distribution of the genotype frequencies and the frequency of allele C (P ＜ 0.05).Conclusion It suggests that rs751141 polymorphism is associated with CHD in Chinese population and the C allele might be a risk factor of CHD.