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Clinical analysis of 34 cases with diffuse alveolar hemorrhage in systemic lupus erythematosus / 实用医学杂志
The Journal of Practical Medicine ; (24): 100-102,106, 2018.
Article in Chinese | WPRIM | ID: wpr-697562
ABSTRACT
Objective To identify the clinical characteristics and therapeutic effect of systemic lupus erythematosus (SLE) patients with diffuse alveolar hemorrhage (DAH).Methods Clinical characteristcs,diagnosis,treatment and outcome in 34 patients hospitalized in The First Affiliated Hospital of Guangxi Medical University from January 2006 to December 2016 were retrospectively analyzed.Results The incidence of DAH involvement of SLE was about 0.39%.Median age was 19 (interquartile range (IQR) 11.75 ~ 32) years.The duration of SLE before clinical DAH was 6 months (IQR 2 ~ 15.75) months.The main clinical manifestations of DAH were cough,dyspnea and fever.The SLE disease activity index (SLEDAI) score was 19.5 (16 ~ 25)points and anti-dsDNA antibody titer elevated markedly (38.2%).The overall mortality rate was 73.5%,however patients who chose department of rheumatism have lower mortality (52.9%).And treatment of CTX was associated with mortality (OR =0.059,95% CI 0.006 ~ 0.554,P =0.013),as well as steroids and immunosuppressant combination therapy.Conclusions The clinical symptoms of SLE with DAH is often atypical.There is manifestation of cough,fever,dyspnea and etc.Imaging and broncoscopy can assist the diagnosis and its prone to the pulmonary infection and high mortality.Early diagnosis and application of CTX combined with conventional dose of hormone theraphy can in early diagnosis and reduce the mortality.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Screening study Language: Chinese Journal: The Journal of Practical Medicine Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Screening study Language: Chinese Journal: The Journal of Practical Medicine Year: 2018 Type: Article