Relationship of NT-ProBNP and IVRT and Ea/Aa in patients with acute cerebral infarction / 实用医学杂志

ABSTRACT

Objective To investigate the relationship of NT-ProBNP,IVRT and Ea/Aa in patients with acute cerebral infarction.Methods From February 2015 to May 2016,67 patients with acute cerebral infarction and 60 healthy subjects were selected as observation group and control group.Sserum NT-proBNP levels and cardiac ultrasound parameters of the two groups were measured.The correlation between NT-ProBNP and left ventricular diastolic function was analyzed,and the ability of NT-ProBNP to detect left ventricular diastolic function was assessed with the ROC curve analysis.Results Compared with those in control group,IVRT and NT-ProBNP of observation group were significantly increased (t =5.844,7.947,P =0.005,0.000),while Ea/Aa was significantly lower (t =4.639,P =0.012).Correlation analysis showed that there was a significant positive correlation between NT-ProBNP and IVRT (r =0.507,P =0.001),and a remarkably negative correlation between NT-ProBNP and Ea/Aa (r =-0.592,P ＜0.001) Multiple linear regression analysis showed that NT-ProBNP was independently correlated with IVRT and Ea/Aa (3 =541.90,26.38).ROC predictive results showed that NT-proBNP had the most optimal sensitivity (100％) and specificity (100％) for detecting Ea/Aa ＜ 1.0 in patients with acute cerebral infarction.Conclusion Serum NT-ProBNP levels can indirectly reflect the severity of left ventricular diastolic dysfunction in patients with acute cerebral infarction.