Clinical value of IL-1β and IL-18 promoted by NLRP3 inflammasome in prognosis prediction of patients with RA-IP / 实用医学杂志

ABSTRACT

Objective To explore the value of IL-1 β and IL-18 in predicting the prognosis of patients with RA-IP.Methods One hundred and five patients diagnosed as RA-IP were involved and their baseline information were recorded.Then,all of the 105 patients were followed-up for 1 year and divided into two groups according to the outcomes of follow-up.The poor prognosis rate of patients was showed by survival curves.Single factor analysis and multiple factors Cox's model analysis were applied to evaluate the influencing degree of factors affecting the prognosis of RA-IP.Meanwhile,the difference of the selected factors of two groups was analyzed and the sensitivity and specificity of the factors in predicting prognosis of patients were calculated by ROC curves.Results The results of single factor analysis and multiple factors Cox's model analysis showed that RF-IgM IL-1 β and IL-18 had influence on the prognosis of patients with RA-IP and IL-1β was the most influential factor (RR =1.624).Compared with those in the favorable group,IL-1 β,IL-18,and the positive numbers of RF-IgM (x2 =4.152,P =0.042) in the unfavorable group were higher.The ROC analysis showed that the AUC of IL-1 β was the highest,and the sensitivity and specificity were 55.9％ and 86.2％,respectively.Conclusion IL-1 β may assess the prognosis of patients with RA-IP.