Effects of non-surgical periodontal therapy combined with emodin on insulin resistance and serum inflam-matory factors in obese rats / 实用医学杂志

ABSTRACT

Objective To investigate the effect of emodin on insulin resistance and serum inflammatory factors in obese rats. Methods 16 obese rats with experimental periodontitis were selected and then randomly di-vided into periodontal treatment group(control group)and periodontal therapy combined with emodin group(medi-cation group). All the rats were sacrificed 2 weeks after treatment. Before the rats were killed,the orbital vein blood was taken to detect fasting blood glucose,fasting insulin;levels of serum C-reactive protein(CRP)and tu-mor necrosis factor-α(TNF-α)were detected by enzyme linked immunosorbent assay.Results 2 weeks after peri-odontal treatment,level of CRP was significantly lower in the medication group than in the control group(t =2.170,P = 0.044);TNF-α was significantly lower in the medication group than in the control group(t = 3.074, P=0.007).Fasting blood glucose level was lower in the medication group than in the control group,and HOMA-β was higher than the control group,no statistical differences were found between the two groups.Conclusions Non-surgical periodontal treatment combined with local administration of emodin can help repair of periodontal epitheli-al barrier and reduce levels of serum inflammatory factors.