Expression of IL-18 in sepsis-associated thrombocytopenia and its clinical significance / 实用医学杂志
The Journal of Practical Medicine
;
(24): 205-208, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-697583
ABSTRACT
Objective To investigate the expression of IL-18 in severe sepsis and sepsis-associated throm-bocytopenia and explore its clinical significance.Methods Real-time polymerase chain reaction was applied to de-tect the expression of IL-18 miRNA in 28 samples of sepsis-associated thrombocytopenia patients and 32 samples of severe sepsis. The enzyme-linked immunosorbent assay was applied to detect the concentration of IL-18 in their plasma. Results The miRNA expression of IL-18 in the sepsis-associated thrombocytopenia group was higher than in the severe sepsis group(P=0.015).The concentration of IL-18 in the severe sepsis-associated thrombocyto-penia group were also higher than those in the severe sepsis group(P=0.034). Conclusion The expression level of IL-18 is related with the severity of thrombocytopenia in patients with sepsis and is likely to play an important role in the pathogenesis of sepsis-associated thrombocytopenia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
The Journal of Practical Medicine
Year:
2018
Type:
Article
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