Effects of different doses of atorvastatin in patients with SAS and coronary artery disease after PCI / 实用医学杂志

ABSTRACT

Objective To assess the effect of perioperative dose atorvastatin on inflammatory status and cardiac function in patients with coronary heart disease complicated by sleep apnea syndrome(SAS)during periop-erative period.Methods A total of 102 patients were enrolled into 3 groups.Group A(n=32)received 80 mg of atorvastatin before PCI,post-PCI follow-up atorvastatin 40 mg for 4 weeks,and atorvastatin 20 mg for 20 weeks;group B(n=32)received no pre-PCI loading dose of atorvastatin but received atorvastatin 40 mg for 4 weeks and then atorvastatin 20 mg for 20 weeks;and group C(n = 38)received only post-PCI atorvastatin 20 mg for 24 weeks.Venous blood samples were collected into Vacutainer tubes from fasting patients on admission(day 0),and 1 day,7 days,4 weeks,and 24 weeks after PCI to measure BNP,MMP-9 and hs-CRP.All the patients underwent echocardiographic assessment on the third day after primary PCI and at the 24th week after a follow-up. Results No differences were found in baseline demographic and angiographic characteristics,and inflammatory factor among the 3 groups. As compared with group C,the average levels of hs-CRP,BNP and MMP-9 in group A de-creased significantly(P<0.05)at different time points during atorvastatin treatment(PCI),and the average level of MMP-9 in group B decreased significantly(P<0.05)after 7 days.At 24 weeks after PCI,LVEF was significant-ly higher in group A and group B than in group C(P<0.05).Conclusions Additional loading-dose atorvastatin before PCI may help prevent inflammatory response and improve cardiac function in patients with SAS complicated by coronary heart disease undergoing PCI.