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Relationship between plasma sclerostin and radiographic severity of knee osteoarthritis / 实用医学杂志
Article in Zh | WPRIM | ID: wpr-697635
Responsible library: WPRO
ABSTRACT
Objective To investigated the relationship between plasma sclerostin(SOST)and knee osteoar-thritis(KOA). Methods A total of 95 patients with KOA and 95 healthy people were involved.Plasma sclerostin, CTX-II, AGG1 and AGG2 levels were measured by ELISA. The 95 patients were divided based on Kellgren-Law-rence classification. The correlation between plasma SOST level and KL classification, CTX-II, AGG1 and AGG2 were analyzed.Results Plasma SOST level in KOA was significantly lower than that in control group(P<0.001). SOST level was negatively correlated with KL grade (r =-0.828,P < 0.001),also with CTX-II (r =-0.917,P <0.001),AGG1 (r =-0.658,P < 0.001) and AGG2 (r =-0.583,P < 0.001). Conclusions SOST level in KOA patients is related to the degree of cartilage degeneration. Thus, it helps to monitor the progress and evaluate the severity of the KOA.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: The Journal of Practical Medicine Year: 2018 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: The Journal of Practical Medicine Year: 2018 Type: Article