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Prevalence of Drug Resistance-Associated Gene Mutations in Plasmodium vivax in Central China
Article in English | WPRIM | ID: wpr-69769
Responsible library: WPRO
ABSTRACT
Resistance of Plasmodium spp. to anti-malarial drugs is the primary obstacle in the fight against malaria, and molecular markers for the drug resistance have been applied as an adjunct in the surveillance of the resistance. In this study, we investigated the prevalence of mutations in pvmdr1, pvcrt-o, pvdhfr, and pvdhps genes in temperate-zone P. vivax parasites from central China. A total of 26 isolates were selected, including 8 which were previously shown to have a lower susceptibility to chloroquine in vitro. For pvmdr1, pvcrt-o, and pvdhps genes, no resistance-conferring mutations were discovered. However, a highly prevalent (69.2%), single-point mutation (S117N) was found in pvdhfr gene. In addition, tandem repeat polymorphisms existed in pvdhfr and pvdhps genes, which warranted further studies in relation to the parasite resistance to antifolate drugs. The study further suggests that P. vivax populations in central China may still be relatively susceptible to chloroquine and sulfadoxine-pyrimethamine.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasmodium vivax / Humans / Drug Resistance / Protozoan Proteins / China / Chloroquine / Prevalence / DNA, Protozoan / Malaria, Vivax / Sequence Analysis, DNA Type of study: Prevalence study Country/Region as subject: Asia Language: English Journal: The Korean Journal of Parasitology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasmodium vivax / Humans / Drug Resistance / Protozoan Proteins / China / Chloroquine / Prevalence / DNA, Protozoan / Malaria, Vivax / Sequence Analysis, DNA Type of study: Prevalence study Country/Region as subject: Asia Language: English Journal: The Korean Journal of Parasitology Year: 2012 Type: Article