Effects of NT-proBNP,blood lactate levels,troponin I and plasma cystatin C on the prognosis of patients undergoing cardiopulmonary bypass / 实用医学杂志

ABSTRACT

Objective To explore the relationship between multiple serological indexes and cardiac prog-nosis risk of patients;To compare the four predictive value of prognosis of patients with cardiac surgery. Meth-ods A total of 127 patients treated by cardiopulmonary bypass surgery were enrolled from July 2013 to March 2015 in our department.Their baseline data were recorded.All patients were followed up for 2 years.Patients with adverse outcomes were defined as the unfavorableprognosis group during the follow-up period while the patients with nodisease progression were defined as the favorableprognosis group. Univariate analysis and Cox proportional risk model wereapplied to evaluate the effects of all factors on the patient's prognosis. Meanwhile,the prediction ability of multiple serological indexes in predicting prognosis of patients with cardiac surgery was calculated by ROC curve analysis. Results Multivariate Cox proportional hazard model showed that the △NT-proBNP(P =0.019),△plasma levels of cystatin C(P=0.037),△troponin I(P=0.028)and LVEF(P=0.045)have signifi-cant influence on the prognosis of the patients and the △NT-proBNP has the highest degree(RR = 1.598);The AUC of the NT-proBNP combined with LVEF in diagnosis of patients with cardiac surgery was 0.842,and the sen-sitivity and specificity were 75.3% and 76.2%,respectively. Conclusions The level of △NT-proBNP and LVEF have a good predictive ability for cardiac outcome in patients undergoing surgery,which is expected as a conven-tional evaluation index of cardiac surgery with cardiopulmonary bypass.