An in vitro activity study of titanium surface modified by cluster-like anatase/rutile nanowires / 实用医学杂志

ABSTRACT

Objective Exploration of the titanium surface nano structure on the cellular bioactivity is of great significance to modifying the pure titanium surface. The unique cluster-like anatase/rutile nanowires (AR@NWs)was prepared and we further examined whether this surface was beneficial for early biological reaction in osteoblast.Methods Unique cluster-like anatase/rutile NWs(AR@NWs)was generated by using a simple hy-drothermal reaction via a three-step synthesis process.The crystal structure of nanowires on titanium surface was de-tected by X-ray diffractometer. The biological activity of nanowires was studied using in vitro cellular experiments. Results The AR@NWs was with a diameter of 200 nm. Three different types of NWs were generated during the production process,displaying different crystal structure and biological characteristics but similar surface topogra-phy and wettability.Compared with sodium titanate NWs(STi@NWs)and H2Ti2O5nanowires(HTi@NWs),AR@NWs surface was conductive to cell attachment. The data indicated that the surface titanium chemical composi-tion and crystal structure played an important role in the cell early response.To some extent,the generation of ana-tase and rutile compensated the cell-repelling properties of NWs. Conclusion Not only the surface physical prop-erties such as surface topography but also the surface chemistry plays an important role in promoting the cell early bioactivity.