The clinical application of pretreatment lactate dehydrogenase/albumin ratio in predicting the prognosis of nasopharyngeal carcinoma / 实用医学杂志

ABSTRACT

Objective To investigate the association between pretreatment serum lactate dehydrogenase (LDH)to albumin ratio(LAR)and the long-term survival of nasopharyngeal carcinoma patients after definite radiotherapy.Methods A total of 956 treatment-naive nasopharyngeal carcinoma patients receiving definite radio-therapy between October 2007 and December 2009 were collected.Univariate and multivariate model were used to analyze the association between pretreatment LAR and overall survival(OS)or distant-metastasis-free survival (DMFS).Results Based on-line cutoff finder,the optimal cut-off value of LAR was determined to be 0.385.Uni-variate analysis reveals that OS and DMFS were all significantly poorer in the high LAR group than that in the low LAR group(P < 0.001). Cox multivariate regression model shows that high LAR(P < 0.001),age ≥ 45 years (P < 0.001)and stage Ⅲ~Ⅳ(P < 0.001)were independent inferior prognostic factors for OS,while high CAR (P < 0.001)and stage Ⅲ~Ⅳ(P = 0.012)were independent inferior prognostic factor for DMFS. Conclusion Pretreatment LAR is an independent prognostic factor in nasopharyngeal carcinoma and could be used in risk strati-fication and guiding adjuvant therapy.