Expressions of IgG,Gab2 and PTEN in human glioma and their clinical significance / 实用医学杂志

ABSTRACT

Objective To investigate the expressions of IgG,Gab2 and PTEN in human gliomas and analyze their relationship with patient prognosis. Methods Immunohistochemistry was performed to detect the expressions of IgG,Gab2 and PTEN in 55 cases of gliomas and 20 cases of normal brain tissues. The mRNA expression of IgG in glioma tissues was detected by in situ hybridization. Results IgG protein and IgG mRNA were expressed in glioma tissues. IgG,Gab2,PTEN expression rate in normal brain tissues was significantly different to that in glioma-tissues(5.0%vs. 69.0%,5.0%vs. 52.7%,and 85.0%vs. 25.5%,P<0.05). Expression of IgG was positively related with expression of Gab2 in glioma(r = 0.3124,P < 0.05),IgG and PTEN expression were negatively related with each other(r=-0.422,P<0.05). Conclusions IgG and Gab2 are highly expressed in glioma. The expression of PTEN was downregulated in glioma. IgG,Gab2 and PTEN might be involved in the development of glioma.