A study on the correlation of VEGF,HSP 70,NBNA score and neonatal asphysia / 实用医学杂志

ABSTRACT

Objective To study on the correlation of VEGF,HSP 70,NBNA score and neonatal asphysia. Methods Using ELISA to detect the expression level of VEGF,HSP 70 in mild asphyxia group,severe asphyxia group and control group. The expression level of VEGF ,HSP 70and the correlation between NBNA score and asphyxia were compared. Results The expression levels of VEGF ,HSP 70 in both mild and severe asphyxia groups were significantly statistically higher than the control group(P<0.05). The severe asphyxia group had even higher VEGF,HSP 70 levels than the mild asphyxia group(P<0.05).The expression level of VEGF,HSP 70 are negatively correlated with the 7 th,14 th,28th-day NBNA score (r=-0.712,-0.629,-0.493;r=-0.621,-0.506,-0.016 ;P < 0.05).The area curve(AUC)for VEGF,HSP 70 leves to predicted respectively were 0.873 (95%CI 0.771~0.892,P<0.05)and 0.815(95%CI 0.729~0.871,P<0.05). Conclusions VEGF,HSP 70 lev-els in umbilical cord blood are closely related to neonatal asphyxia.The more severe the asphyxia ,the higher the expression level of VEGF and HSP 70,and the lower the NBNA score.