Research progress of intercellular adhesion molecule-1 in tumor / 实用肿瘤学杂志

ABSTRACT

Intercellular adhesion molecule(ICAM-1),also known as CD54,is a transmembrane glycoprotein of the immuno-globulin superfamily and involved in tumor cell immune regulation,angiogenesis,invasion and distant metastasis.Many studies from domestic and abroad have proved that ICAM-1 is highly expressed in a variety of malignant tumors,which promotes the occurrence, development and prognosis of tumor.ICAM-1 also plays an important role in predicting the chemosensitivity of individual tumors. Therefore,ICAM-1 may provide a reference for the diagnosis and treatment of malignant tumors.This article summarizes effects of ICAM-1 on malignant tumors in recent years.