Effects of Dane Fukang Jiangao combined with GnRH-a in preventing recurrence of postoperative endometriosis / 天津医药

ABSTRACT

Objective To observe the clinical efficacy of Dane Fukang Jiangao combined with gonadotropin-releasing hormone analogue(GnRH-a)in the treatment of endometriosis(EMT)after laparoscopic surgery. Methods A total of 120 EMT patients treated with GnRH-a after laparoscopic surgery were randomly divided into combine treatment group(n=60) and control group (n=60). In the control group, GnRH-a 3.75 mg was injected subcutaneously on the first day of menstruation and injected once every 28 days. The combine treatment group was given Dane Fukang Jiangao with oral administration 10 g per time, twice a day for 6 months. The changes of estradiol (E2), CA125 and visual analogue scale (VAS)were observed before and after treatment.Kupperman score was used to assess the degree of menopausal symptoms during treatment and follow-up records of recurrence. Results Before treatment, there were no significant differences in the serum levels of E2 and CA125 and VAS between both groups.After treatment,the serum levels of E2 and CA125 and VAS were significantly improved in both groups. And the serum level of E2 was significantly higher in combine treatment group than that of control group (P<0.05). The VAS and the serum level of CA125 were significantly lower than those of control group(P<0.05).Moreover,after treatment the Kuppermann score was significantly better in combine treatment group than that of control group (P<0.05). There was no significant difference in the recurrence rate in 6 months between the combine treatment group (21.7%) and the control group (38.3%, P>0.05). Conclusion Dane Fukang Jiangao in combination with GnRH-a can effectively prevent E2 from being too low,reduce the CA125 level after EMT surgery,relieve dysmenorrhea and menopausal symptoms,and prevent recurrence.