Correlation of serum uric acid levels and carotid lesions in H type hypertension patients with type 2 diabetes mellitus / 天津医药

ABSTRACT

Objective To analyze changes of serum uric acid (SUA) and carotid lesions in H type hypertension patients with type 2 diabetes mellitus (T2DM) and explore the risk factors of H type hypertension with T2DM. Methods A total of 119 patients diagnosed as H-type hypertension and admitted to our hospital from November 2016 to December 2017 were included in this study. Patients were divided into two groups according to whether they were combined with T2DM 64 cases in simple H type hypertension group (simple group) and 55 cases in H type hypertension combined with T2DM group (combined group). Fifty healthy people in healthy physical examination at the same period were enrolled in this study as the control group. Questionnaires (age, gender, hypertensive history, cerebrovascular history, smoking history and drinking history) were collected in patients. The blood biochemical indicators including homocysteine (Hcy), SUA, fasting plasma glucose (FPG), triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were detected. The color Doppler ultrasonography was used to measure carotid intima-media thickness (cIMT). The carotid plaque scores were also measured. The risk factors of H type hypertension with T2DM were analyzed by multivariate Logistic regression. Results Values of SUA, cIMT incrassation ratio, carotid plaque score, carotid plaque detection rate, cerebrovascular history, smoking history and drinking history in simple group was higher than control group and lower than combined group (P＜0.05). Data of hypertension and Hcy were increased in simple group and combined group (P＜0.05). The serum level of FPG was significantly higher in combined group than that of control group and simple group (P＜0.05). There were no significant differences in hypertensive history, blood pressure and Hcy between simple group and combined group. There were no significant differences in TC, TG, HDL-C and LDL-C between three groups. Multivariate Logistic regression analysis showed that the elevated SUA ( OR=1.015, 95% CI 1.008-1.023), cIMT incrassation ( OR=13.754, 95% CI 2.556-74.016) and smoking history ( OR=5.229, 95% CI 2.872-9.775) were risk factors for H type hypertension with T2DM. Conclusion For patients with hypertension and T2DM, Hcy, SUA and cIMT should be routinely tested, which can take corresponding intervention at early stage to prevent atherosclerosis and control the occurrence of cardiovascular and cerebrovascular diseases effectively.