Immunoregulatory mechanism of mesenchymal stem cells on the T and B cells in systemic lupus erythematosus / 中国组织工程研究

ABSTRACT

BACKGROUND:Studies have shown that the main functions of stem cells include secreting soluble factors,regulating immune balance,suppressing inflammatory response,directional differentiation into specific functional cells involved in tissue repair,promoting revascularization,improving blood circulation and anti-oxidative stress.Therefore,stem cells can be applied for treatment of autoimmune diseases,especially systemic lupus erythematosus.OBJECTIVE:To summarize the immunoregulatory mechanism of mesenchymal stem cells on T and B lymphocytes in systemic lupus erythematosus.METHODS:A computer-based online search of CNKI and PubMed from January 2006 to August 2016 was performed by the first author to search related articles with the keywords of “mesenchymal stem cell,systemic lupus erythematosus,immunoregulation” in Chinese and English,respectively.Articles related to the immunomodulatory effect of mesenchymal stem cells in the treatment of systemic lupus erythematosus were selected,and as for in the same field,literatures published lately in the authoritative journals were preferred.RESULTS AND CONCLUSION:A total of 207 literatures were initially selected,and finally 53 articles were involved in analysis according to the inclusion criteria.Mesenchymal stem cells have the potential of self-renewal and multi-directional differentiation,which are ideal seed cells for immune replacement therapy.Meanwhile,mesenchymal stem cells can treat autoimmune diseases radically because of the ability of immunoregulation.Currently,mesenchymal stem cells have been proved to be a safe and effective therapeutic measure in the treatment of systemic lupus erythematosus,which can avoid drug side effects and have a great clinical prospect.However,there are still numerous problems to be solved in clinic.