Role of stromal cell-derived factor 1/CXC chemokine receptor axis in rat tooth movement / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 5757-5762, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-698307
ABSTRACT
BACKGROUND:
Orthodontic treatment has a long course and referral interval,which is an important difficulty.How to accelerate orthodontic tooth movement is an issue of concern.OBJECTIVE:
To testify whether the local injection of AMD3100 (CXCR4 antagonist) can accelerate the tooth movement or not,and to explore the role of stromal cell-derived factor 1/CXC chemokine receptor axis in tooth movement.METHODS:
Ninety Sprague-Dawley rats aged 8-10 weeks old were selected and the models of orthodontic tooth movement were established.The model rats were randomized into three groups,and then given the injection of stromal cell-derived factor 1,AMD3100 or PBS.The rats were killed at 1,3,5,7,10 and 14 days to measure the tooth movement distance.RESULTS ANDCONCLUSION:
The tooth movement distance showed difference among three groups;AMD3100 could facilitate the tooth movement,while stromal cell-derived factor 1 exerted inhibitory effect on the tooth movement.To conclude,stromal cell-derived factor 1/CXC chemokine receptor axis plays an important role in tooth movement.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
/
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2017
Type:
Article
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