Synthesis and biological properties of strontium-substituted hydroxyapatite / 中国组织工程研究

ABSTRACT

BACKGROUND:Hydroxyapatite is the main mineral component of bone and teeth.It is non-immunogenic and osteoinductive and suitable for bone repair.Strontium and calcium are cognate elements in the periodic table of elements and it has been proved that strontium has dual effects,namely,osteogenic promotion and suppression of osteoclast activity.OBJECTIVE:To summarize the preparation of strontium-substituted hydroxyapatite and its biological properties.METHODS:The first author searched the PubMed database for related literature from 1990 to 2017.The key words were "strontium;substituted;doped;containing;hydroxyapatite".The literatures obtained were screened,and the irrelevant and repetitive literatures were excluded.RESULTS AND CONCLUSION:The preparation methods of strontium-substituted hydroxyapatite include liquid-phase method (hydrothermal method,acid-base neutralization and sol-gel method) and solid-phase method (mechanochemical method).In addition,strontium-substituted hydroxyapatite coating can be produced by electrochemical deposition and micro-arc oxidation.The introduction of strontium significantly modifies the crystal size,crystallinity,solubility and mechanical properties,and improves the biocompatibility,pro-osteogenesis and osteoclast inhibition of hydroxyapatite,but the optimal proportion of strontium needs to be further explored.Furthermore,the immune-regulation and osteogenic properties under pathological conditions of strontium-substituted hydroxyapatite need to be further improved.