Effects of titanium implant surface modification on macrophage polarization and osteogenesis / 中国组织工程研究

ABSTRACT

BACKGROUND: A single use of bone-forming cells to evaluate the biological properties of titanium implant materials cannot meet the demands of early and long-term stable osseointegration. In order to fulfill the objective mentioned above, it is necessary to understand the interaction between implant and body at the interface of implantation. It is also urgent to consider the invaluable function of immunological factors including macrophage, so as to guide the implant surface modification. OBJECTIVE: To review the influence of physical, chemical and biological surface modifications of implants on the macrophage polarization and osteogenesis.METHODS: The first author conducted a computer-based retrieval of PubMed, Springerlink, Web of Science, ScienceDirect, CNKI, CqVip and WanFang databases for relevant articles published from January 2010 to December 2017. The key words were "titanium, implant, macrophage, polarization, osteogenesis" in English and Chinese, respectively. RESULTS AND CONCLUSION: Macrophages represent the first and the most abundant cells in contact with these implant materials and act as main effector cells in the intrinsic immune response. Surface modifications of implants play an important role in osseintegration by a M1"tissue-inflammatory" polarization or M2 "wound-healing" activation. Furthermore, implant surface modification also affects the osteoinductive ability of macrophage. Future research intends to explain the bone healing mechanism between implant and host tissues from the immunological aspect and develop new-type titanium implants. New surface modification methods of implants, which could induce osteogenesis and acquire bone coupling and homeostasis, will be developed to fulfill early-and long-term stable osseointegration.