In vitro evaluation of silver ion implantation into titanium dioxide coating against Staphylococcus aureus / 中国组织工程研究

ABSTRACT

BACKGROUND: It is a challenge to seek for ideal anti-bacterial surface modification by which silver ions can have sustained and durable release. OBJECTIVE: To investigate the in vitro characteristics and effect of titanium dioxide coating with silver ion injection against Staphylococcus aureus . METHODS: There were four groups in the study control group (pure titanium), titanium oxide coating group, low silver ion group (titanium oxide coating+30 minutes injection of silver ions), and high silver ion group (titanium oxide coating+60 minutes injection of silver ions). Characteristics of the implanted material in each group were observed using scanning electron microscope. Antibacterial efficacy for Staphylococcus aureus was assessed through bacterial instillation method, antibacterial ring test, and microbial growth curve. RESULTS AND CONCLUSION: Silver ions could be loaded onto the surface of the titanium dioxide coating through the silver ion implantation. Moreover, the number of silver ions on the coating surface and the antibacterial ability of the modified coating were both increased with the extension of injection time. Therefore, the silver ion implantation technology is beneficial to prepare inorganic antibacterial materials with strong and long-lasting antibacterial ability.