Research progress of intracellular high mobility group box B1 / 中国小儿急救医学
Chinese Pediatric Emergency Medicine
;
(12): 630-632, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-699019
ABSTRACT
High mobility group box 1 ( HMGB1 ) is a highly conserved DNA-binding protein. The function of HMGB1 varied according to its molecular localization. Meanwhile,HMGB1 is located in the nu-cleus under physiological conditions. It contains stable nucleosome structure and can promote gene recombina-tion,repair,transcription etc,known as the"DNA chaperone". Intracellular HMGB1 has a protective effect on heart hypertrophy, heart failure, pancreatitis, hepatic ischemia/reperfusion injury, spinocerebellar ataxia and other protective effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pediatric Emergency Medicine
Year:
2018
Type:
Article
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