Relationship between interleukin-7 and the adaptive immune disorders in sepsis / 中国小儿急救医学

ABSTRACT

Sepsis remains the leading cause of death of patients in pediatric intensive care unit. The adaptive immune dysfunction affects the occurrence and development of sepsis. Recent studies have found that interleukin-7 plays a critical part in the immune cell activation,proliferation and maturation,and it may have important means in the immune reconstitution in sepsis. Immunosuppression,the biological function of inter-leukin-7,the immune cell regulation and its application progress in sepsis were reviewed in this article.