Comparison of Total Body Irradiation (TBI) Conditioning with Non-TBI for Autologous Stem Cell Transplantation in Newly Diagnosed or Relapsed Mature T- and NK-Cell Non-Hodgkin Lymphoma / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 92-103, 2017.
Article
in English
| WPRIM
| ID: wpr-6991
ABSTRACT
PURPOSE:
This retrospective study was conducted for comparison of survival outcomes and toxicities of autologous stem cell transplantation (ASCT) based on the use of total body irradiation (TBI) as a part of the conditioning regimen in patients with mature T- and natural killer (NK)-cell lymphomas. MATERIALS ANDMETHODS:
Patients who underwent ASCT in the upfront or salvage setting between January 2000 and December 2013 were analyzed. Patients were dichotomized according to the TBI group (n=38) and non-TBI group (n=60) based on the type of conditioning regimen for ASCT.RESULTS:
Patients with responsive disease underwent upfront ASCT (TBI, n=16; non-TBI, n=29) whereas patients with refractory disease (TBI, n=9; non-TBI, n=12) or relapsed disease (TBI, n=13; non-TBI, n=19) underwent ASCT after salvage treatment. Hematologic and non-hematologic toxicities were manageable, and the median cumulative toxicity score according to Seattle criteria was estimated as 2 (range, 0 to 7) in both groups. No significant difference in 100-day mortality was observed between the TBI (13%, 5/38) and non-TBI (12%, 12/60) groups, and most deaths were related to disease progression. There was no difference in overall and progression-free survival; however, the TBI group showed a trend of better survival in upfront and salvage ASCT than the non-TBI group. However, patients with refractory disease showed the worst outcome regardless of the use of TBI. Patients who showed complete response before ASCT showed better progression-free survival than thosewho showed partial response.CONCLUSION:
TBI could be used as an effective part of conditioning for ASCT in patients with mature T- and NK-cell lymphomas.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Lymphoma, Non-Hodgkin
/
T-Lymphocytes
/
Retrospective Studies
/
Mortality
/
Whole-Body Irradiation
/
Salvage Therapy
/
Disease-Free Survival
/
Disease Progression
/
Stem Cell Transplantation
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2017
Type:
Article
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