Influence of L-carnitine combined coenzyme Q10 on hsCRP,cTnI and BNP levels in patients with chro-nic heart failure / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine
;
(6): 195-199, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-699381
ABSTRACT
Objective:
To explore influence of L-carnitine combined coenzyme Q10 on levels of high sensitive C reac-tive protein(hsCRP),cardiac troponin I(cTnI)and brain natriuretic peptide(BNP)in patients with chronic heart failure(CHF).Methods:
A total of 100 CHF patients were randomly and equally divided into routine treatment group(received metoprolol tartrate + losartan + spironolactone treatment)and combined treatment group(re-ceived L-carnitine + coenzyme Q10 based on routine treatment),and both groups were treated for four weeks. Levels of hsCRP,cTnI and BNP and heart function were compared between two groups before and after treatment.Results:
Total effective rate of combined treatment group was significantly higher than that of routine treatment group(94.0% vs.70.0%,P=0.002).Compared with before treatment,there were significant reductions in levels of hsCRP,cTnI and BNP and left ventricular end-diastolic dimension(LVEDd),and significant rise in left ventricu-lar fractional shortening(LVFS)and left ventricular ejection fraction(LVEF)after treatment in two groups,P<0.01 all;compared with routine treatment group after treatment,there were significant reductions in levels of hsCRP[(3.44 ± 0.15)mg/L vs.(2.82 ± 0.31)mg/L],cTnI[(0.25 ± 0.03)μg/L vs.(0.17 ± 0.01)μg/L],BNP [(259 ± 34)ng/L vs.(215 ± 37)ng/L]and LVEDd[(57.9 ± 10.1)mm vs.(47.4 ± 9.2)mm],and significant rise in LVFS[(29.1 ± 4.7)% vs.(32.9 ± 8.9)%]and LVEF[(60.1 ± 9.7)% vs.(65.8 ± 4.9)%]in combined treat-ment group after treatment,P<0.05 or <0.01. Second hospitalization rate within one year of combined treatment group was significantly lower than that of routine treatment group(4.7% vs.18.6%), P=0.044.Conclusion:
L-carnitine combined coenzyme Q10 can significantly reduce levels of hsCRP,cTnI and BNP,improve heart function with definite therapeutic effect and it can improve prognosis in CHD patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of cardiovascular Rehabilitation Medicine
Year:
2018
Type:
Article
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