Therapeutic effect of vitamin D combined benazepril on reducing urine microalbumin in hypertensive patients / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine
;
(6): 286-289, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-699405
ABSTRACT
Objective:
To study safety and effectiveness of vitamin D combined benazepril on patients with essential hyper-tension (EH) and positive urine microalbumin (UMA).Methods:
A total of 92 EH patients with positive UMA were ran-domly divided into benazepril group (n=44 , received benazepril 5md/d ,placebo 1 capsule/d) and combined treatment group (n=48 , received vitamin D3 400mg/d and benazepril 5mg/d) ,both groups were treated for 12 weeks.Levels of mean arterial pressure (MAP) ,serum creatinine (SCr) and UMA were measured and compared between two groups before and after treatment .Results:
Compared with before treatment ,there were significant reductions in levels of MAP and UMA in two groups after treatment , P=0.001 all ;compared with benazepril group ,there were significant reductions in levels of MAP [ (108.45 ± 15.09) mmHg vs.(101.1 ± 15.02) mmHg] and UMA [ (52.35 ± 17.45) mg/L vs.(43.75 ± 13.29) mg/L] in combined treatment group ,P<0.05 or <0.01.There was no significant difference in SCr level between two groups before and after treatment , P>0.05 all.Conclusion:
Compared with pure benazepril antihypertensive treat-ment ,vitamin D combined benazepril possesses better therapeutic effect on reducing UMA and antihypertensive effect .And it is safe without obvious damage on kidney function ,which is worth extending .
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Chinese Journal of cardiovascular Rehabilitation Medicine
Year:
2018
Type:
Article
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