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Effects of intracoronary tirofiban injection during PCI in advanced aged patients with ST elevation my-ocardial infarction / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine ; (6): 326-331, 2018.
Article in Chinese | WPRIM | ID: wpr-699415
ABSTRACT

Objective:

To study effects of intracoronary tirofiban injection during percutaneous coronary intervention (PCI) in advanced aged patients with ST elevation myocardial infarction (STEMI).

Methods:

A total of 116 ad-vanced aged STEMI patients undergoing PCI in our hospital were selected .According to random number table ,they were randomly and equally divided into routine treatment group (received routine PCI ) and tirofiban group (re-ceived routine PCI combined tirofiban ).Serum N terminal pro brain natriuretic peptide (NT-proBNP) level on 12h , 24h ,72h and 7d after PCI ,TIMI blood flow grade and incidence rate of hemorrhage on 7d after PCI ,left ventricu-lar end-diastolic volume index (LVEDVI) ,left ventricular end-systolic volume index (LVESVI) and left ventricular ejection fraction (LVEF) before and one year after PCI ,incidence rate of adverse cardiac events on one year after PCI were observed and compared between two groups .

Results:

Serum NT-proBNP level of tirofiban group on 12h , 24h ,72h and 7d after PCI was significantly lower than that of routine treatment group , P=0.001 all.On 7d after PCI ,percentage of TIMI grade 3 in tirofiban group was significantly higher than that of routine treatment group (93.11% vs .62.07%,P=0.001).Compared with routine treatment group on one year after PCI ,there was signif-icant rise in LVEF [ (41.95 ± 4.18)% vs .(47.18 ± 4.83)% ] ,and significant reductions in LVESVI [ (43.03 ± 4.21) ml/m2vs.(39.42 ± 3.87) ml/m2] ,LVEDVI [ (62.05 ± 6.17) ml/m2vs.(58.46 ± 5.91) ml/m2] and inci-dence rate of adverse cardiac events (37.93% vs.18.97%) in tirofiban group , P<0.05 or <0.01. There were no significant difference in incidence rate of hemorrhage between two groups , P> 0. 05 .

Conclusion:

Intracoronary tirofiban injection during PCI in advanced aged STEMI patients can significantly improve myocardial blood flow , cardiac function and reducing incidence rates of adverse cardiac events ,which is worth extending in clinic .

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2018 Type: Article