Relationship between procalcitonin level and spontaneous recanalization of infarct related artery in patients with myocardial infarction / 心血管康复医学杂志

ABSTRACT

Objective:To explore relationship between procalcitonin (PCT) level and spontaneous recanalization (SR) of infarct related artery in patients with myocardial infarction (MI).Methods:The 109 MI patients from our coro-nary care unit (CCU) were divided into SR group (n＝45 ,TIMI blood flow grade 2～3) and no SR group (n＝64 , TIMI blood flow grade 0 －1) according to TIMI blood flow grade .General data ,biochemical indexes were com-pared between two groups ,influencing factors of infarct related artery SR were analyzed ,and ROC curve of PCT level predicting infarct related artery SR was drawn .Results:Compared with no SR group ,there were significant reductions in levels of LDL-C [ (2.57 ± 0. 61 ) mmol/L vs.(2.13 ± 0.62 ) mmol/L ] , lipoprotein a (Lp (a )) [ (234.16 ± 72.67) mg/L vs.(182.62 ± 69.35) mg/L] ,PCT [ (0.12 ± 0.05) μg/L vs .(0.07 ± 0.04) μg/L] , hsCRP [ (6.05 ± 3.68) mg/L vs.(3.12 ± 2.53) mg/L] and creatine kinase isoenzyme MB (CK-MB) [ (85.56 ± 23.67) U/L vs.(74.36 ± 22.65) U/L] in SR group , P＜0.05 or ＜0.01. Logistic multi-factor regression analysis indicated that PCT level was independent predictive factor for coronary SR (OR＝0.661 , P＝0.001).Area under ROC curve was 0.760 for PCT predicting coronary SR , P＝0.001 ,95% CI 0.645－0.874 ,optimal cutoff point was 0.085μg/L ,and sensitivity and specificity was 84.4% and 65.4% respectively .Conclusion:PCT is independent predictive factor for infarct related ar-tery SR in MI patients.When PCT level ＜0.085μg/L ,artery SR rate tends to increase .