Influence of Wenxin granule combined propranolol on related hormone levels and cardiac function in patients with hyperthyroidism and atrial fibrillation / 心血管康复医学杂志

ABSTRACT

Objective: To observe influence of Wenxin granule combined propranolol on related hormone levels and cardiac function in patients with hyperthyroidism and atrial fibrillation (AF).Methods:A total of 136 AF patients with hyperthyroidism diagnosed in our hospital were randomly and equally divided into propranolol group and com-bined treatment group (received propranolol combined Wenxin granule ).Both groups received routine treatment for eight weeks also .Serum levels of free triiodothyronine (FT3) ,free thyroxine (FT4) and thyrotropic-stimulating hormone (TSH) ,blood pressureSBP 、 DBP ,HR and LVEF before and after treatment were compared between two groups.Results:Compared with before treatment ,there were significant reductions in serum levels of FT 3 and FT4 ,SBP ,DBP and HR ,and significant rise in serum TSH level and LVEF after treatment ,in two groups , P＜0.05 or ＜0.01. Compared with propranolol group after treatment ,there were significant reductions in serum levels of FT3 [ (6.68 ± 1.94) pmol/L vs.(4.39 ± 1.34) pmol/L] and FT4 [ (28.67 ± 5.17) pmol/L vs .(22.67 ± 4.86) pmol/L] ,SBP [ (127.79 ± 10.86) mmHg vs.(121.76 ± 9.43) mmHg] ,DBP [ (81.65 ± 8.41) mmHg vs.(75.12 ±8.16) mmHg] and HR [ (85.67 ± 7.64) beats/min vs .(80.79 ± 6.47) beats/min] ,and significant rise in serum TSH level [ (1.28 ± 0.26) mU/L vs.(1.81 ± 0.34) mU/L] and LVEF [ (56.28 ± 5.12)% vs.(59.76 ± 4.25)%] in combined treatment group ,P＜0.05 or ＜0.01. Total effective rate of combined treatment group was significant-ly higher than that of propranolol group (95.59% vs.82.35%,P＝0.014).There was no significant difference in incidence of adverse reactions between two groups , P＝1.000 .Conclusion:Wenxin granule combined propranolol can significantly improve thyroid hormone levels and cardiac function in patients with hyperthyroidism ,which is worth extending .