Clinical significance of renal artery ultrasound hemodynamic index and advanced oxidation protein product in evaluating the renal function level in preeclampsia pregnant women / 新乡医学院学报

ABSTRACT

Objective To explore the clinical significance of renal artery ultrasound hemodynamic index and advanced oxidation protein product(AOPP)in evaluating the renal function level in preeclampsia pregnant women. Methods Seventy two cases of preeclampsia pregnant women in the Central Hospital of Zhumadian City were divided into mild group(39 cases)and se-vere group(33 cases)according to the pathogenetic condition,and 35 healthy pregnant women who were hospitalized and deliv-ered in the same period were selected as the control group. Ratio of systolic to diastolic(S/ D),pulsation index(PI),resistance index(RI)of renal artery were detected by color Doppler ultrasound in all patients. The levels of plasma AOPP and serum creati-nine(Cr),uric acid(UA),cystatin C(Cys C),blood urea nitrogen(BUN)were detected. The results among the three groups were analyzed. Results The S/ D,PI,RI of renal artery,the levels of plasma AOPP and serum Cr,Cys C,BUN in the severe group were significantly higher than those in the mild group and the control group(P <0. 05). The S/ D,PI,RI of renal artery,the levels of plasma AOPP and serum Cys C in the mild group were significantly higher than those in the control group(P < 0. 05). There was no significant difference in the level of serum Cr and BUN between the mild group and the control group(P >0. 05). There was no significant difference in the serum UA level among the three groups(P >0. 05). The results of Pearson correlation analysis showed that the S/ D,PI,RI of renal artery and AOPP were positively correlated with the level of Cys C(r =0. 557,0. 621,0. 597, 0. 608;P <0. 05),but they was not correlated with the level of serum Cr,UA and BUN(r =0. 133,0. 159,0. 215;P >0. 05). The S/ D,PI,RI of renal artery were positively correlated with the level of plasma AOPP(r = 0. 582,0. 639,0. 633;P < 0. 05). Con-clusion Detection of renal artery hemodynamic parameters and AOPP level can help to predict renal function in preeclampsia pregnant women.