Preliminary clinical research on liquid-immersion femtosecond laser assisted cataract surgery / 眼科新进展

ABSTRACT

Objective To observe the safety and effectiveness of liquid-immersion femtosecond laser assisted cataract surgery (FLACS).Methods A prospective study was conducted in together 70 age-related cataract patients (70 eyes) between October 2013 and April 2014,and these subjects were randomly divided into two groupsFLACS group,35 patients undergoing liquid-immersion LensAR FLACS,and ultrasound group,35 patients receiving conventional phacoemuisification.All patients were followed up 1 day,1 week,1 month and 3 months after operation.The variables,including uncorrected distance visual acuity (UCVA),best corrected distance visual acuity (BCVA),redness analysis,corneal thickness,aqueous humor protein concentration and corneal endothelial cell count were recorded and analyzed.Results All procedures in the FLACS group were successful.The ultrasound time and energy in the FLACS group were statistically less than those in the ultrasound group[(23.25 ±7.21)s,(7.91％ ±2.75％)vs.(34.08 ± 8.59) s,(16.95％ ± 4.60％)] (both P =0.000).The LogMAR UCVA and LogMAR BCVA were better and the corneal thickness in FLACS group were statistically less than those in the ultrasound group postoperative 1 day and 1 week (all P ＜ 0.05).And the corneal endothelial cell loss rate in the FLACS group was statistically lower than that in the ultrasound group postoperative 1 week and 3 months [(9.63％ ±3.67％),(11.22％ ±3.77％) vs.(13.29％ ±4.62％),(15.16％ ±5.02％)] (allP=0.000).One day,1 week and 1 month after operation,the aqueous humor protein concentration in the FLACS group [(16.88 ±4.76)nc · s-1,(14.12 ±4.96)nc · s-1,(9.71 ± 3.83)nc · s 1] was lower than those in the ultrasound group (all P ＜ 0.05).However,there was no significant difference in conjunctival hyperemia and ciliary congestion between the two groups at 1 day after operation (all P ＞ 0.05).Conclusion The liquid-immersion FLACS is efficient and safe for assisting cataract surgery that may have some advantages in reducing tissue damage and improving postoperative early visual recovery.