The relaxation of zonule in primary angle closure suspects / 眼科新进展

ABSTRACT

Objecttve To compare the difference of relaxation distribution of zonule in different orientations between primary angle closure suspects (PACS) and normal controls,and to explore the role of latent subluxated lens in the pathogenesis of glaucoma.Methods Together 19 eyes of 19 PACS (PACS group) and 19 eyes of 19 age-,gender-and eye-matched normal controls (control group) were enrolled in this study.Pentacam was performed under standardized dark conditions before and 30 min after instillation of compound tropicamide eye drop.Peripheral anterior chamber depth (peri-ACD) of 8 orientations (superior,temporal superior,temporal,temporal inferior,inferior,nasal inferior,nasal,nasal superior position) in the central 4 mm diameter was measured automatically in each eye.The differences of peri-ACD (△ peri-ACD) before and after mydriasis were measured to reflex the relaxation of zonule.The difference of peri-ACD in 8 orientations after mydriasis could confirm the possibility of latent subluxated lens,and its range could verify the degree of lens deviation.Results Significant difference was observed in each groups in terms of △peri-ACD (P＜0.001,0.043).The △peri-ACD of the temporal inferior position was (0.40 ± 0.28)mm in PACS group,which was smaller than that in the control group [(0.55 ±0.15)mm] (P =0.041),but no significant difference was observed between PACS patients and normal controls in other orientations (all P ＞ 0.05).And significant difference was detected between the 8 positions of peri-ACD after mydriasis in each groups (P =0.001,0.009),and these parameters between the two groups were also significantly different (all P ＜ 0.01).Moreover,there was no significant difference in the difference of between the minimum and maximum peri-ACD in the PACS group and the control group [(0.35 ± 0.18)mm vs.(0.43 ± 0.28) mm] (P =0.362).Conclusion The uneven relaxation distribution of zonule may exist in both PACS patients and normal controls,and the relaxation of zonule may be significant in temporal inferior position in PACS patients.