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Association between Metformin Use and Survival in Nonmetastatic Rectal Cancer Treated with a Curative Resection: A Nationwide Population Study / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 29-36, 2017.
Article in English | WPRIM | ID: wpr-6997
ABSTRACT

PURPOSE:

Metformin is associated with an anticancer effect. However, the effects of metformin in rectal cancer are controversial. This study investigated the impact of metformin on the survival of patients with diabetes mellitus and nonmetastatic rectal cancer who underwent curative surgery. MATERIALS AND

METHODS:

The database was provided by the Korea Center Cancer Registry and National Health Insurance Service of the Republic of Korea. A cohort of patients with newly diagnosed rectal cancer between 2005 and 2011 was identified. Drug exposure was defined as receiving the oral hypoglycemic agent for at least 90 days over the period from 6 months before the initial diagnosis of rectal cancer to the last follow-up.

RESULTS:

A total of 4,503 patients were prescribed oral hypoglycemic agents and classified as the diabetic group, of which 3,694 patients received metformin for at least 90 days. Unadjusted analyses showed a significantly higher overall survival (hazard ratio, 0.596; 95% confidence interval, 0.506 to 0.702) and rectal cancer-specific survival (hazard ratio, 0.621; 95% confidence interval, 0.507 to 0.760) in the metformin group than in the nonmetformin group. The adjusted overall survival (hazard ratio, 0.631; 95% confidence interval, 0.527 to 0.755) and cancer-specific survival (hazard ratio, 0.598; 95% confidence interval, 0.479 to 0.746) in the group with a medication possession ratio of 80% or greater was significantly higher than in the group with a medication possession ratio of less than 80%.

CONCLUSION:

Metformin use is associated with overall and cancer-specific survival in diabetic patients with a nonmetastatic rectal cancer treated with a curative resection.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Rectal Neoplasms / Cohort Studies / Follow-Up Studies / Colorectal Surgery / Diabetes Mellitus / Diagnosis / Republic of Korea / Hypoglycemic Agents / Korea / Metformin Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Cancer Research and Treatment Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rectal Neoplasms / Cohort Studies / Follow-Up Studies / Colorectal Surgery / Diabetes Mellitus / Diagnosis / Republic of Korea / Hypoglycemic Agents / Korea / Metformin Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Cancer Research and Treatment Year: 2017 Type: Article