Clinical features and prognosis of lacrimal gland adenoid cystic carcinoma with high-grade transformation / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology
;
(12): 442-448, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-699761
ABSTRACT
Objective To summarize the clinical characteristics and prognosis of lacrimal gland adenoid cystic carcinoma with high-grade transformation (LACC-HGT).Methods A retrospective study was adopted.Seventeen patients with lacrimal gland adenoid cystic carcinoma (LACC) were collected from August 2008 to March 2017 in Tianjin Medical University Eye Hospital.Hematoxylin-eosin staining and immunohistochemical staining were performed on tumor sections of 17 LACC patients.According to the pathology results,the patients were divided into LACC-HGT group (6 patients) and non-LACC-HGT (NLACC-HGT)group (11 patients),and the clinical characteristics and prognosis of the two groups were analyzed by using Fisher's exact test and Log-Rank test.Results The medical histories,clinical features,imaging features,TNM staging and treatment protocols were not significantly different between the two groups (all at P> 0.05).The 2-year local recurrence rate,5-year distant metastasis rate and 5-year death rate of patients with LACC-HGT were significantly higher than patients with NLACC-HGT (all at P<0.05).Survival analysis results showed that the survival time of LACC-HGT group was obviously shorter than that of NLACC-HGT group.Conclusions LACC-HGT accelerate the invasion process of local recurrence and distant metastasis,and enhance the death rate.The detection of HGT components should be considered in the process of LACC diagnosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Practice guideline
/
Observational study
/
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Experimental Ophthalmology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS