The visual basis of the biological clock "sees" the light:intrinsically photosensitive retinal ganglion cells / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology
;
(12): 879-882, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-699838
ABSTRACT
Mammalian eyes mediate both image-forming and non-image-forming visual functions. Non-image-forming vision provides a measure of the ambient light for the purposes of synchronization of circadian clocks to light/dark cycles and regulation of pupil size,pineal melatonin production and other functions. Traditionally,people used to believe that the classical photoreceptors (rods and cones) regulate both image-forming and non-image-forming visual pathways. However,a small subset of retinal ganglion cells called intrinsically photosensitive RGCs ( ipRGCs) has been identified to be a third type of mammalian photoreceptor and determined to be photosensitive, recently. The discovery of ipRGCs has allowed for rapid progress in the past decade toward understanding the non-image-forming visual system,especially about how the circadian clock complete the synchronization with the light/dark cycle. The anatomical and developmental characteristics of ipRGCs, as well as its biological functions and regulation were reviewed in this paper.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Experimental Ophthalmology
Year:
2018
Type:
Article
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