Clinical efficacy of carbamazepine, topiramate combined with levetiracetam in the treatment of traumatic refractory epilepsy / 中国医师进修杂志

ABSTRACT

Objective To study the effect of carbamazepine, topiramate combined with levetiracetam in the treatment of traumatic refractory epilepsy. Methods One hundred patients with traumatic intractable epilepsy from January 2014 to January 2017 were studied prospectively.They were divided into 2 groups by random digits table method with 50 cases each group.The control group received topiramate combined with carbamazepine, and the observation group was given carbamazepine, topiramate combined with levetiracetam treatment. All cases were treated for 6 months. The clinical efficacy of the 2 groups, patients with epilepsy, cognitive function score and the incidence of adverse reaction were compared. Results The total effective rate in observation group was 96% (48/50), in control group was 82% (41/50), and there was statistical difference (P<0.05). The number of seizures and epilepsy duration after treatment in observation group and control group were significantly lower than that before treatment (2.84 ± 1.06) times/month vs. (6.18 ± 2.21) times/month and (4.09 ± 1.23) times/month vs.(6.24 ± 2.17)times/month,(1.25 ± 0.58)h/time vs.(2.75 ± 0.92)h/time and(1.97 ± 0.74) h/time vs. (2.83 ± 0.90) h/time, moreover those after treatment in observation group were significantly lower than those in control group,and there were statistical differences(P<0.05).The mini-mental state examination (MMSE) scores and Montreal cognitive assessment (MoC-A) scores after treatment in 2 groups were significantly higher than those before treatment, moreover those after treatment in observation group were significantly lower than those in control group, and there were statistical differences(P<0.05).There was no statistical difference in incidence of drug adverse reaction between control group and observation group8%(4/50)vs.4%(2/50),P>0.05.Conclusions The clinical effect of carbamazepine, topiramate combined with levetiracetam on traumatic intractable epilepsy can effectively reduce the onset and duration of epilepsy,and improve the cognitive function of patients.The risk of adverse reactions did not increase.This treatment is reliable and safe.