Postoperative FP ( 5-Fluorouracil , Cisplatin ) Chemotherapy for Patients with High - Risk Gastric Cancer / 대한암학회지
Journal of the Korean Cancer Association
;
: 482-487, 1998.
Article
in Korean
| WPRIM
| ID: wpr-70021
ABSTRACT
PURPOSE:
Although adjuvant chemotherapy after resection of gastric cancer is a popular practice in Korea, there are still controversies about the effectiveness of the treatment. The fact that the relatively less effective drugs have been used and the rarity of large-scaled controlled studies may be partially responsible for the controversies. FP(5-FU, Cisplatin) combination is one of the most active regimen against advanced gastric cancer, consistently showing a response rate of 50~60%. We tried the FP chemotherapy as an adjuvant treatment for high-risk patients after curative resection of gastric cancer. MATERIALS ANDMETHODS:
Between February 1992 and June 1996, 35 patients with completely resected high-risk gastric cancer(postoperative stage III or IV except thase with M1) received six courses of FP chemotherapy. Endpoints were toxicities of treatment, relapse free survival, and overall survival.RESULTS:
With a median follow-up time of 17.1 months, Kaplan-Meier estimates of 2-year overall survival was 63.3% and relapse free survival estimates was 49%. There were no differences between stage III and IV patients in terms of overall survival or relapse free survival. Hematologic and non-hematologic toxicities were tolerable for most of the patients.CONCLUSION:
Postoperative FP combination chemotherapy was tolerable for patients with high-risk(stage III and IV) gastric cancer. It is too early to determine the long term survival rates for this patients, but 2-year overall and relapse free survival were comparable to that of historical non-cisplatin containing regimens. Randomized phase III studies are warranted.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Stomach Neoplasms
/
Survival Rate
/
Follow-Up Studies
/
Cisplatin
/
Chemotherapy, Adjuvant
/
Drug Therapy
/
Drug Therapy, Combination
/
Fluorouracil
/
Korea
Type of study:
Controlled clinical trial
/
Etiology study
/
Observational study
/
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of the Korean Cancer Association
Year:
1998
Type:
Article
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