Relationship between plasma endothelin-1 and nitric oxide levels and hearing impairment in elderly patients with hyperuricemia / 中国医师进修杂志

ABSTRACT

Objective To investigate the relationship between plasma endothelin-1 and nitric oxide levels and hearing impairment in elderly patients with hyperuricemia (HUA). Methods The clinical data of 174 physical examination elderly from September 2013 to March 2016 were retrospectively analyzed. Among them, the HUA was in 81 cases (HUA group), and no HUA was in 93 cases (control group). The pure tone hearing and high stimulation rate of auditory brainstem response were tested, and the plasma endothelin and nitric oxide levels were detected. Results The pure tone hearing of 250, 500, 1 000,2 000, 4 000 and 8 000 Hz in HUA group were significantly higher than those in control group (33.03 ± 12.09) dB vs. (28.49 ± 9.89) dB, (35.56 ± 13.47) dB vs. (27.31 ± 9.34) dB, (38.81 ± 14.94) dB vs. (29.78 ± 9.39) dB, (43.62 ± 16.45) dB vs. (37.06 ± 12.66) dB, (51.07 ± 18.36) dB vs. (46.29 ± 15.15) dB and (65.75 ± 18.76) dB vs. (57.71 ± 20.26) dB, and there were statistical differences (P＜0.01). The Ⅰ wave, Ⅲ wave, Ⅴ wave latency and Ⅰ to Ⅲ wave, Ⅰ to Ⅴwave intervals in HUA group were significantly longer than those in control group (2.10 ± 0.26) ms vs. (2.03 ± 0.24) ms, (4.11 ± 0.38) ms vs. (3.89 ± 0.31) ms, (5.94 ± 0.31) ms vs. (5.69 ± 0.29) ms, (2.01 ± 0.26) ms vs. (1.86 ± 0.22) ms and (3.83 ± 0.28) ms vs. (3.65 ± 0.25) ms, and there were statistical differences (P＜0.01). There was no statistical difference inⅢtoⅤwave interval between 2 groups (P＞0.05). The Ⅴ wave threshold value in HUA group was significantly higher than that in control group(45.61 ± 11.18) dB vs. (41.98 ± 9.37) dB, and there was statistical difference (P＜0.05). The plasma endothelin-1 level in HUA group was significantly higher than that in control group (16.96 ± 3.45) ng/L vs. (11.64 ± 3.81) ng/L, the plasma nitric oxide level was significantly lower than that in control group(0.98 ± 0.66) μmol/L vs. (1.36 ± 1.08) μmol/L, and there were statistical differences (P＜0.05 or＜0.01). Conclusions Elevated plasma endothelin-1 level and reduced nitric oxide level may be a possible mechanism for hearing impairment in elderly patients with hyperuricemia.