Experimental study on the change of interleukin- 6 and 10 in abdominal compartment syndrome / 中国医师进修杂志

ABSTRACT

Objective To explore the changes of interleukin (IL)-6 and IL-10 in the model of abdominal compartment syndrome. Methods From January 2016 to December 2017, fifteen New Zealand rabbits were divided into control group (5 rabbits) and experimental group (10 rabbits) 2 groups according to the drawing of lots. The liquid animal model of abdominal high pressure was made. Pressurized water sac in the control group was not injected fluid to maintain the pressure of 0 mmHg (1 mmHg＝ 0.133 kPa). Pressure was regulated in 25 mmHg (grade 3) in experimental group. The IL-6 and IL-10 levels were compared between 2 groups. Results The IL-6 and IL-10 2 and 24 h after operation in experimental group were significantly higher than those in control group (9.99 ± 2.88) and (7.57 ± 2.31) μg/L vs. (0.19 ± 0.05) μg/L, (59.28 ± 19.32) and (33.18 ± 13.14) mg/L vs. (13.25 ± 5.56) mg/L, and there were statistical differences (P＜0.01). Conclusions In the development of abdominal compartment syndrome, both IL-6 and IL-10 levels are significantly elevated, suggesting that there is mixed antagonism response syndrome.