A Case of Successful Danazol Therapy in Autoimmune Thrombocytopenia Associated with Systemic Lupus Erythematosus
Journal of the Korean Pediatric Society
;
: 1330-1333, 2001.
Article
in Korean
| WPRIM
| ID: wpr-70074
ABSTRACT
Autoimmune thrombocytopenia and autoimmune hemolytic anemia occur in 10-26% of patients with systemic lupus erythematosus(SLE). These hematological manifestations may be the sole presenting sign and can precede the appearance of diagnosable SLE in 5 to 23% of cases. The conventional treatment for SLE associated with these disorders includes corticosteroid therapy and splenectomy, but autoimmune thrombocytopenia or autoimmune hemolytic anemia may be refractory to both treatments. We experienced a case of a SLE patient complicated by severe autoimmune thrombocytopenia. Therapy with intravenous immunoglobulin and corticosteroids failed. She responded to danazol and remission of thrombocytopenia(platelet >100,000/mm3) was observed 7 days after starting danazol. Danazol therapy seems to be a useful and well tolerated treatment for refractory autoimmune thrombocytopenia associated with SLE.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Splenectomy
/
Immunoglobulins
/
Purpura, Thrombocytopenic, Idiopathic
/
Adrenal Cortex Hormones
/
Danazol
/
Anemia, Hemolytic, Autoimmune
/
Lupus Erythematosus, Systemic
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
2001
Type:
Article
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