The research progress of asymmetric dimethylarginine in chronic kidney disease / 医学研究生学报

ABSTRACT

Asymmetric dimethylarginine (ADMA) is a naturally occurring amino acid found in tissues and cells that circulates in plasma and is excreted in urine. As an inhibitor for nitric oxide synthases,ADMA produces considerable biological effects and severs as a risk marker of endothelial dysfunction and cardiovascular complications. Several recent lines of evidence suggest that ADMA has been associated with the progression of chronic kidney disease. Several potential mechanisms may be compromise of the integrity of the glomerular filtration barrier and development of renal fibrosis. In this review, we summary the existing literatures on the biology and physiology of ADMA on their associations with diseases,especially focusing on its role in the progression of chronic renal disease.