The function and association between PD-L1 and Treg cells in tumor immunity / 医学研究生学报
Journal of Medical Postgraduates
;
(12): 198-203, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-700802
ABSTRACT
Programmed death-1 (PD-1) is the member of the inhibitory costimulatory molecules,has its ligand (programmed death ligand 1,PD-L1),expressing on the surface of a variety of tumor cells.PD-1/PD-L1 plays an important role in the negative regulation of immune responses,promoting tumor immune escape.Regulatory T cell (Treg) is a kind of T cell subsets with immunosuppressive effect,which is highly expressed in tumor tissues,and plays a role in immune tolerance.Recent studies demonstrate key roles of PD-L1 in promoting iTreg cell development and function.This paper gives a brief review of their immune regulations and the association between PD-L1 and Treg.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2018
Type:
Article
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