Progression in the diagnosis and treatment of Bile acid diarrhea / 医学研究生学报
Journal of Medical Postgraduates
;
(12): 333-336, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-700829
ABSTRACT
Bile-acid diarrhoea(BAD)is a common cause of chronic diarrhoea,resulting from the excess amounts of bile acids enter the colon.The understanding of people about the cause of this diarrhea is still relatively limited for a variety of reasons.Clin-ically,75SeHCAT is the first-line diagnostic test,Other diagnostic tests including the measurement of serum 7α-hydroxy-4-cholesten-3-one(C4)、serum fibroblast growth factor 19(FGF19)、fecal bile acids and the empirical treatment of bile acid sequestrants(BAS). First-line treatment is with BAS for BAD,primarily cholestyramine,Newer BAS such as colestipol and colesevelam have fewer side effects. Obeticholic acid(OCA),as a new drug,maybe have a significant future.This article gives an overview on the etiology,pathogen-esis、diagnosis and treatment progress of BAD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2018
Type:
Article
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