Effect of Advanced Glycation End Products, Serum Anti-müllerian Hormone and Serum Inhibin B on Reproductive Organ Maturation in Children with Type 1 Diabetes Mellitus / 医学研究杂志

ABSTRACT

Objective To investigate the effect of Children with type 1 diabetes mellitus on reproductive organ maturation.Methods 80 cases of 6-10 years old patients with type 1 diabetes Tanner stages Ⅰ were enrolled,including 41 girls and 39 boys;control group 85 cases,including 40 girls and 45 boys.We detected serum AGEs,AMH,INHB,four steroid sex hormones and HbA1 c levels respectively.Results Compared with the control group,girls with type 1 diabetes had a significant increase of serum AGEs,AMH,INHB and HbA1c level(P ＜ 0.05).Four steroid sex hormones had no statistically significant differences between girls with type 1 diabetes and control group(P ＞ 0.05).Compared with the control group,boys with type 1 diabetes have a significant increase of serum AGEs,AMH,HbA1c level and decrease of INHB(P ＜ 0.05).Four steroid sex hormones had no statistically significant differences between boys with type 1 diabetes and control group(P ＞ 0.05).Conclusion Children with type 1 diabetes mellitus has a negative impact on reprodu-tive organ maturation.