Influence of Combined Detection of Serum Midkine and TBIL Levels in Diagnostic Efficacy of Diabetic Retinopathy / 医学研究杂志

ABSTRACT

Objective To explore the diagnostic efficacy of combined detection of serum midkine (MK) and total bilirubin (TBIL)levels of diabetic retinopathy(DR),and determine the value in diagnosis of DR.Methods Clinical data of 215 cases of patients with type 2 diabetes mellitus (T2DM) treated in our hospital from July 2014 to December 2016 were collected,and diabetes mellitus without retinal lesions (NDR) in 79 cases,non-proliferative diabetic retinopathy (NPDR) in 81 cases,proliferative diabetic retinopathy (PDR) in 55 cases.Another 70 cases of physical examination persons in the same period were as the control group.Serum MK and TBIL levels were detected in the four groups,and the relationship between indexes and DR was done by Person correlation analysis and Logistic regression analysis,and diagnostic efficacy of Midkine and TBIL was evaluated in DR.Results Serum MK and TBIL levels were compared between the four groups,with statistically significant differences (P ＜ 0.05).MK level increased in normal control group,NDR group,NPDR group and PDR group,while TBIL levels decreased in each group.MK was positively correlated with DR (r =0.779,P =0.005),and TBIL was negatively correlated with DR (r =-0.657,P =0.012),and both were independent factors influencing DR (OR =2.257,0.681,P ＜ 0.05).The sensitivity of combined detection of MK and TBIL in diagnosis of DR was higher than that of each index detected separately (P ＜ 0.05).Conclusion Serum MK and TBIL levels are closely related to the occurrence of DR and severity of the disease,and the combined detection has high diagnostic efficacy for DR.