Effect of Losartan Combined Folic Acid on Heart Rate Variability in H-type Hypertension Patients Complicated with Acute Cerebral Infarction / 医学研究杂志

ABSTRACT

Objective To investigate the effect of losartan combined folic acid on heart rate variability in H-type hypertension patients complicated with acute cerebral infarction.Methods Fifty six cases of H-type hypertension complicated with acute cerebral infarction patients admitted to our hospital were collected from March 2016 to March 2017,and were randomly divided into the study group and the control group,each with 28 cases.The research team were treated with losartan tablet 50mg/d and folic acid tablet 0.8mg/d;and the control group were treated with osartan tablet 50mg/d alone.The changes of heart rate variability and serum homocysteine levels were compared between two groups.Results When compared with the control group,the systolic blood pressure reduced more (t =2.878,P =0.006) in the study group,but there was no statistical significance in diastolic blood pressure (P ＞ 0.05).After treatment,the SDNN significantly increased (t =2.267,P =0.027),SDANN significantly increased (t =2.106,P =0.039);RMSSD significantly increased (t =2.192,P =0.032),PNN50 significantly increased (t =2.889,P =0.006).LF significantly increased (t =2.024,P =0.048),HF significantly increased (t =2.365,P =0.022),LF/HF significantly decreased (t =2.195,P =0.033) in the study group.The serum homocysteine level of study group was significantly decreased (t =4.958,P =0.000) after treatment,and significantly lower than the control group (t =4.710,P =0.000).Conclusion The combination of losartan and folic acid can effectively improve the heart rate variability in H-type hypertension patients complicated with acute cerebral infarction.