Correlation Between Paraoxonase-1 Gene Q192R Polymorphism and Clopidogrel Resistance / 医药导报

ABSTRACT

Objective To investigate the correlation between Paraoxonase-1 (PON-1) gene Q192R polymorphism and clopidogrel resistance (CR). Methods A total of 118 patients with coronary artery disease diagnosed by coronary angiography or coronary artery CT angiography were enrolled. Platelet aggregation rate was assessed by ADP-induced light-transmittance aggregometry after the patients received adequate clopidogrel pretreatment.The patients were divided into (clopidogrel resistance group (CR group) and non-clopidogrel resistance group (NCR group) according to the ADP-induced platelet aggregation rate. The gene of Q192R was detected by MassARRAY Time of Flight Mass Spectrometry.The genotypes and allele frequencies between the two groups were compared. Results According to the ADP-induced platelet aggregation rate,25 patients were defined as clopidogrel resistant and 93 as non-clopidogrel resistant.The incidence of clopidogrel resistance was 21.2％.Three frequencies of genotype RR,QR and QQ were 36. 0％,52. 0％ and 12. 0％ in CR group, and 32. 2％,57. 0％ and 10. 8％ in NCR group, respectively.The frequencies of Q and R allele in CR group were 62.0％ and 38.0％,and those in NCR group were 60.8％ and 39.2％.No significant differences in genotype and allele frequency were found between CR group and NCR group (P>0.05). Conclusion The PON-1 gene Q192R polymorphism is not associated with clopidogrel resistance in patients with CHD.